Toxicological Evaluation of Disulfiram, Copper Gluconate and Disulfiram/Copper Gluconate Combination on Renal Function in Rodents
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Evaluation of the suppressive effect on bitter taste of gluconate.
Gluconate is used as an additive in a wide range of processed foods. In this study, we investigated its utility as a taste-improving substance. To determine whether it has a suppressive effect on bitter taste, sensory evaluations were performed by human subjects. When gluconate was added to a quinine-HCl (QHCl) solution, the taste intensity decreased, but this effect was not observed when it wa...
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A mutant lacking gluconate-6-phosphate dehydrase (the first enzyme of the Entner-Doudoroff pathway) was isolated after ethyl methane sulfonate mutagenesis of Escherichia coli. Other enzymes of gluconate metabolism (gluconokinase, gluconate-6-phosphate dehydrogenase, and 2-keto-3-deoxygluconate-6-phosphate aldolase) were present in the mutant. When the mutant was grown on gluconate-1-(14)C, alan...
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Sclerosing agents as zinc gluconate-based chemical sterilants (Infertile®) are used for chemical castration. This solution is injected into the animal testis, but there are not enough evidences of its safety profiles for the receivers. The present work aimed to establish the pharmacokinetics and toxicological activity of Infertile, using in vitro and in silico approaches. The evaluation at the ...
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3. Sicart M, Besse P, Choussat A, Bricaud H: Action hemodynamique de l'amiodarone intra-veineuse chez l'homme. Arch Mal Coeur 3: 219, 1977 4. Charlier R, Delaunois G, Bauthier J: Caracteristiques et mecanismes de l'action de l'aamiodarone sur le debit cardiaque. Arzneimihel-Forschung 22: 1968, 1972 5. Charlier R, Delaunois G, Bauthier J: Incidence de l'amiodarone et de quelques beta-bloquants s...
متن کاملExperimental evaluation of chlorhexidine gluconate for ocular antisepsis.
Chlorhexidine gluconate is a bisguanide germicide currently available with 70% isopropanol (Hibistat, Hibitane) or a detergent (Hibiclens, Hibiscrub) for preoperative skin preparation. As these solvents are toxic to the cornea, we investigated the safety and efficacy of aqueous chlorhexidine solutions for ophthalmic use. Chlorhexidine in Tris-glycine buffer was evaluated for retardation of epit...
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ژورنال
عنوان ژورنال: Pharmacology & Pharmacy
سال: 2015
ISSN: 2157-9423,2157-9431
DOI: 10.4236/pp.2015.62011